Effects of post-coital administration of chlormadinone acetate to rats.
نویسندگان
چکیده
Different doses (ranging from 31 to 1000 \g=m\g)of chlormadinone acetate were injected into female rats on Days 2 to 6 ofpregnancy. The percentage of ova lost before implantation increased with higher doses of the drug, whereas the implantation ratio (number of rats with implantations/total number of rats) was not affected by treatment. The dose of 1 mg altered the onset ofparturition in 50% of the rats.
منابع مشابه
Comparative study of DNA repair induced by cyproterone acetate, chlormadinone acetate and megestrol acetate in primary cultures of human and rat hepatocytes.
Cyproterone acetate (CPA), a synthetic progestin recently found to induce genotoxic effects in hepatocytes from female rats and from humans of both genders, and two structural analogues, chlormadinone acetate (CMA) and megestrol acetate (MGA), have been compared for their capacity to induce DNA repair synthesis as measured by quantitative autoradiography. Exposure of primary human hepatocytes f...
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ورودعنوان ژورنال:
- Journal of reproduction and fertility
دوره 39 1 شماره
صفحات -
تاریخ انتشار 1974